Newest Articles
IFT is restricted to a subset of microtubulesIntraflagellar transport (IFT) is the movement of large protein complexes responsible for the construction of cilia and flagella. Using a combination of three-dimensional electron microscopy and high-resolution live imaging, Bertiaux et al. show that IFT takes place on only four microtubule doublets out of the nine available in the trypanosome flagellum.
Dynamic control of pulsed contractilityPulsed actomyosin contractility underlies many morphogenetic processes. Here, Michaux et al. show that, in early C. elegans embryos, pulsed contractions are generated by intrinsically excitable RhoA dynamics, involving fast autoactivation of RhoA and delayed negative feedback through local actin-dependent recruitment of the RhoGAPs RGA-3/4.
Interaction of Legionella DrrA with exocystLegionella pneumophila enters cells in a vacuole derived from the plasma membrane, which then sequesters vesicles from the ER in order to support parasite growth and immune evasion. Arasaki et al. now reveal that the Legionella effector DrrA recruits components of the exocyst to promote tethering of host vesicles with the LCV.
Structural basis of MAP4–microtubule interactionThe Tau family of microtubule-associated proteins promote microtubule stabilization or regulate microtubule-based motility. Shigematsu et al. visualized MAP4 and microtubules complexed with kinesin-1 by cryo-EM, which suggests a structural basis of microtubule stabilization and kinesin inhibition by Tau family MAPs.
Chromosome interlock removal during meiosisDuring meiosis, unrelated chromosomes frequently become interlocked, and these structures must be removed for complete synapsis and normal chromosome segregation. Martinez-Garcia et al. show that the active removal of interlocks requires topoisomerase II and chromosome movement.
Histone regulation during the cell cycleMendiratta et al. review the interplay between the different regulatory layers that affect the transcription and dynamics of distinct histone H3 variants along the cell cycle.
Chromatin reprogramming to totipotency in embryosLadstätter and Tachibana discuss changes in DNA methylation, chromatin accessibility, and topological architecture occurring during the reprogramming to totipotency in the early embryo.
Talin as a mechanosensitive signaling hubGoult et al. propose that talin acts as series of mechanochemical switches to form a mechanosensitive signaling hub that integrates adhesion signaling.
GTP hydrolysis promotes atlastin dimer disassemblyThe GTPase atlastin mediates homotypic ER fusion through trans-crossover dimerization, but how dimerization is coupled to the GTPase cycle has remained unclear. Winsor et al. show that GTP binding causes crossover dimerization for fusion, whereas GTP hydrolysis promotes disassembly of the crossover dimer for subunit recycling.
Cadherins are gatekeepers of Fas death receptorControl of epithelial cell death is crucial to maintaining tissue integrity. Gagnoux-Palacios et al. show that cell polarity and adherens junction formation prevent proapoptotic signals emanating from the Fas death receptor. Therefore, Fas-dependent cell death contributes to the elimination of nonpolarized or nonadherent cells from human epithelia.
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Current Issue
November 5, 2018
Volume 217, No. 11
