Newest Articles
Ykt6 in autophagosome fusionAutophagosome fusion with vacuoles requires a conserved fusion machinery, though the topology remained unclear. Two papers in this issue, Bas et al. and Gao et al., uncover Ykt6 as the required autophagosomal SNARE.
Ykt6 mediates autophagosome–vacuole fusionAutophagosome fusion with vacuoles requires a conserved fusion machinery, though the topology remained unclear. Two papers in this issue, Bas et al. and Gao et al., uncover Ykt6 as the required autophagosomal SNARE.
Cyclin B and oocyte meiosisCyclin B1 and its interaction with CDK1 are thought to be critical for meiosis I progression in oocytes. However, using oocyte-specific conditional knockouts, Li et al. show that Cyclin B2 activity can compensate for Cyclin B1 to trigger meiosis resumption.
VPS13 proteins transfer lipids at membrane contact sitesStructural and biochemical studies show that VPS13 family proteins are lipid transporters. VPS13A and VPS13C tether the ER to mitochondria and to endosomes/lysosomes, respectively, suggesting lipid dyshomeostasis as the cause of chorea acanthocytosis and Parkinson’s disease resulting from their mutations.
TMEM41B is required for autophagosome formationMorita et al. identify the endoplasmic reticulum multispanning membrane protein TMEM41B as a factor required for autophagosome formation. TMEM41B interacts physically and functionally with VMP1, a structurally related autophagy protein.
The stem cell niche is protected from apoptosisIrradiation temporarily arrests tissue regeneration. Volin et al. show that the ability of stem cells to regain regeneration relies on the resistance of their niche-supporting cells to apoptosis. This resistance is mediated by microRNAs that prevent apoptosis induction.
INPP5K and ER architectureEndoplasmic reticulum (ER) morphology is dynamic and key to its function during different cellular processes. Dong et al. now show in convergent studies in human cells and Caenorhabditis elegans neurons that a phosphoinositide phosphatase (INPP5K) is localized on the surface of the ER network and helps control the shape of the ER.
Novel structure of Vps1 helical assemblyHow specific dynamin-related proteins (DRPs) are tailored to their cellular targets is an open question. Varlakhanova et al. present structures of the fungal DRP Vps1, which functions at the endosomal compartment. The crystal and cryoEM structures reveal a unique DRP architecture that highlights structural flexibilities of DRP self-assembly.
A novel microtubule nucleation pathway in oocytesRomé and Ohkura show that the kinesin-6 Subito/MKlp2 mediates a novel oocyte-specific microtubule nucleation pathway, which is essential for assembling spindle microtubules complementarily with the Augmin pathway.
Oligomerization of Yurt controls polarityThe ability of the polarity protein Yurt to bind to Crumbs and to maintain epithelial cell polarity depends on its oligomerization. aPKC-dependent phosphorylation dismantles the Yurt oligomer to maintain Crumbs function and apical domain integrity in polarized epithelial cells.
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Current Issue
September 3, 2018
Volume 217, No. 9
