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Newest Articles

  • Molecular determinants of ER–Golgi contacts identified through a new FRET–FLIM system
    FRET-based analysis of ER–TGN contact sites

    Venditti et al. develop a novel FRET- and FLIM-based approach to monitor ER–trans Golgi network (TGN) contacts and identify VAP proteins, OSBP1, ORP9, and ORP10 as required to maintain contacts. OSBP1 and ORP9 play redundant structural roles, whereas ORP10’s requirement depends on its ability to transfer phosphatidylserine to the TGN.

    Rossella Venditti ... Maria Antonietta De Matteis
    Tools | January 18, 2019
  • The activity of Sac1 across ER–TGN contact sites requires the four-phosphate-adaptor-protein-1
    FAPP1 controls SAC1 activity at ER–TGN contacts

    Venditti et al. identify FAPP1 as a new determinant of ER–trans-Golgi network contacts that interacts with the phosphoinositide phosphatase Sac1 and promotes its phosphatase activity. The results suggest that, by controlling PI4P levels, FAPP1 acts as a gatekeeper of cargo Golgi exit.

    Rossella Venditti ... Maria Antonietta De Matteis
    Report | January 18, 2019
  • Xiaochen Wang: Building up our understanding of breaking down
    Xiaochen Wang: Building up our understanding of breaking down

    Wang studies lysosomal degradation pathways using C. Elegans as a model system.

    Nicole Infarinato
    People & Ideas | January 17, 2019
  • Myosin IIB assembly state determines its mechanosensitive dynamics
    Myosin IIB assembly defines mechanoresponsiveness

    Schiffhauer et al. use mathematical modeling of Dictyostelium myosin II and experimental approaches in mammalian cells to demonstrate that multiple inputs modulate the ability of myosin II to assemble into filaments. These inputs integrate to govern the myosin II mechanoresponsiveness.

    Eric S. Schiffhauer ... Douglas N. Robinson
    Article | January 17, 2019
  • Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin
    Saccharopine is a mitochondrial toxin

    Leandro and Houten highlight new work from Zhou et al. exploring the disease relevance and toxicity of lysine metabolites in mitochondria.

    João Leandro ... Sander M. Houten
    Spotlight | January 16, 2019
  • Dendritic cells mature to resist lamin degradation and herpes virus release
    Autophagy degrades lamin for herpesvirus egress

    Florence Niedergang introduces work by Turan et al. demonstrating that herpes virus egress from dendritic cells is differentially regulated by kinesin-dependent positioning of lysosomes and autophagic degradation of nuclear lamins.

    Florence Niedergang
    Spotlight | January 15, 2019
  • Detaching the tether: Remodeling mitochondrial localization during meiosis
    Remodeling mitochondrial localization during meiosis

    Soni Lacefield discusses new findings from Sawyer et al. revealing the developmental regulation of mitochondrial detachment from the cell cortex during meiosis.

    Soni Lacefield
    Spotlight | January 15, 2019
  • A mosaic of old and young nucleoporins
    A mosaic of old and young Nups

    Shimi and Kimura preview work from the Hetzer laboratory visualizing nuclear long-lived proteins, histones and nucleoporins, and the pattern of nucleoporin renewal, providing insight into protein longevity in nuclear maintenance and its function.

    Takeshi Shimi ... Hiroshi Kimura
    Spotlight | January 15, 2019
  • ATM is activated by ATP depletion and modulates mitochondrial function through NRF1
    ATM regulates ATP levels through NRF1

    Oxidative stress, resulting from neuronal activity and depleted ATP levels, activates ATM, which phosphorylates NRF1, causing nuclear translocation and up regulation of mitochondrial gene expression. In ATM deficiency, ATP levels recover more slowly, particularly in active neurons with high energy demands.

    Hei-Man Chow ... Karl Herrup
    Article | January 14, 2019
  • Correction: Going the distance: Neocentromeres make long-range contacts with heterochromatin
    Shannon M. McNulty ... Beth A. Sullivan
    January 11, 2019

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The Journal of Cell Biology: 218 (2)

Current Issue

February 4, 2019
Volume 218, No. 2

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Online ISSN: 1540-8140
Print ISSN: 0021-9525

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